Prof. Dr. med.
Kaspar Z’graggen

Specialist in Surgery FMH

Visiting Fellow, Dept. of Surgery Ninewells Hospital, University of Dundee / Scotland

Tiefenauspital Berne (Prof. F Nöthiger)

Doctorate University of Berne

Aarberg Hospital (Dr. C. Klaiber)

Medical studies FMGEMS / ECFMG

Doctor's degree

Medical studies Fribourg / Berne

Head of Surgical Oncology Section Surgical University Hospital Clinic for General, Visceral and Trauma Surgery Heidelberg, Germany

First Senior Physician Surgical University Hospital Clinic for General, Visceral and Trauma Surgery Heidelberg, Germany

Senior Physician, Clinic for Visceral and Transplant Surgery Inselspital University of Berne

Senior Physician, Surgical Clinic Tiefenauspital Berne

Klinik Beau-Site
Establishment and management of the training centre V1 for visceral surgery

Co-founder World Pancreas Forum 
Congress President 2015, 2017, 2020 in Berne

Doctors' Network Berne
Co-President

Klinik-Beau-Site Berne
Member and President of the Medical Council

Full Professorship University of Lausanne

Case-matched study of lesser versus greater curvature approach in laparoscopic Warshaw pancreatectomy.

Müller PC, Müller SA, Steinemann DC, Pärli MS, Moltzahn F, Schmid SW, Z’graggen K.

Am J Surg. 2017 Apr;213(4):711-717.

Role of proteomics to differentiate between benign and potentially malignant pancreatic cysts.

Cuoghi A, Farina A, Z’graggen K, Dumonceau JM, Tomasi A, Hochstrasser DF, Genevay M, Lescuyer P, Frossard JL.J

Proteome Res. 2011 May 6;10(5):2664-70

Chronic pancreatitis is associated with disease-specific regulatory T-cell responses.

Schmitz-Winnenthal H, Pietsch DH, Schimmack S, Bonertz A, Udonta F, Ge Y, Galindo L, Specht S, Volk C, Z’graggen K, Koch M, Büchler MW, Weitz J, Beckhove P.

Gastroenterology. 2010 Mar;138(3):1178-88

Early results from a randomized clinical trial of colon J pouch versus transverse coloplasty pouch after low anterior resection for rectal cancer.

Ulrich AB, Seiler CM, Z’graggen K, Löffler T, Weitz J, Büchler MW.

Br J Surg. 2008 Oct;95(10):1257-63

Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases.

Kleeff J, Diener MK, Z’graggen K, Hinz U, Wagner M, Bachmann J, Zehetner J, Müller MW, Friess H, Büchler MW.

Ann Surg. 2007 Apr;245(4):573-82

Specific immune recognition of pancreatic carcinoma by patient-derived CD4 and CD8 T cells and its improvement by interferon-gamma.

Schmitz-Winnenthal FH, Escobedo LV, Beckhove P, Schirrmacher V, Bucur M, Ziouta Y, Volk C, Schmied B, Koch M, Antolovic D, Weitz J, Büchler MW, Z’graggen K.

Int J Oncol. 2006 Jun;28(6):1419-28

Expression of cytokeratin-20 in pancreatic cancer: an indicator of poor outcome after R0 resection.

Schmitz-Winnenthal FH, Volk C, Helmke B, Berger S, Hinz U, Koch M, Weitz J, Kleeff J, Friess H, Zöller M, Büchler MW, Z’graggen K.

Surgery. 2006 Jan;139(1):104-8.

High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients.

Schmitz-Winnenthal FH, Volk C, Z’graggen K, Galindo L, Nummer D, Ziouta Y, Bucur M, Weitz J, Schirrmacher V, Büchler MW, Beckhove P.

Cancer Res. 2005 Nov 1;65(21):10079-87

Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility.

Gesierich S, Paret C, Hildebrand D, Weitz J, Z’graggen K, Schmitz-Winnenthal FH, Horejsi V, Yoshie O, Herlyn D, Ashman LK, Zöller M.

Clin Cancer Res. 2005 Apr 15;11(8):2840-52.

Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy.

Büchler MW, Wagner M, Schmied BM, Uhl W, Friess H, Z’graggen K.

Arch Surg. 2003 Dec;138(12):1310-4

Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.

Z’graggen K, Warshaw AL, Werner J, Graeme-Cook F, Jimenez RE, Fernández-Del Castillo C.

Ann Surg. 2001 May;233(5):688-95

Biological implications of tumor cells in blood and bone marrow of pancreatic cancer patients.

Z’graggen K, Centeno BA, Fernandez-del Castillo C, Jimenez RE, Werner J, Warshaw AL.

Surgery. 2001 May;129(5):537-46

A new surgical concept for rectal replacement after low anterior resection: the transverse coloplasty pouch.

Z’graggen K, Maurer CA,  Kern B, Büchler MW.

Ann Surg. 2001 Dec;234(6):780-5

Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1.

Werner J, Z’graggen K, Fernández-del Castillo C, Lewandrowski KB, Compton CC, Warshaw AL.

Ann Surg. 1999 Jun;229(6):834-40

Middle segment pancreatectomy: a novel technique for conserving pancreatic tissue.

Warshaw AL, Rattner DW, Fernández-del Castillo C, Z’graggen K.

Arch Surg. 1998 Mar;133(3):327-31

Metastases to the pancreas and their surgical extirpation.

Z’graggen K, Fernández-del Castillo C, Rattner DW, Sigala H, Warshaw AL.

Arch Surg. 1998 Apr;133(4):413-7

Cytotoxic cells are activated in cellular infiltrates of alcoholic chronic pancreatitis.

Hunger RE, Mueller C, Z’graggen K, Friess H, Büchler MW.

Gastroenterology. 1997 May;112(5):1656-63.

The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease.

Z'Graggen K, Walz A, Mazzucchelli L, Strieter RM, Mueller C.

Gastroenterology. 1997 Sep;113(3):808-16.

Acute postoperative pancreatitis after laparoscopic cholecystectomy. Results of the Prospective Swiss Association of Laparoscopic and Thoracoscopic Surgery Study.

Z’graggen K, Aronsky D, Maurer CA, Klaiber C, Baer HU.

Arch Surg. 1997 Sep;132(9):1026-30

Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.

Z’graggen K, Rivera JA, Compton CC, Pins M, Werner J, Fernández-del Castillo C, Rattner DW, Lewandrowski KB, Rustgi AK, Warshaw AL.

Ann Surg. 1997 Oct;226(4):491-8