Pankreas Klinik Schweiz

Prof. Dr. med.
Kaspar Z’graggen

Founder and Chief Physician of the Pancreas Clinic Switzerland

About Prof. Dr. med. Kaspar Z’graggen

Prof. Dr. med. Kaspar Z'graggen is head of the Pancreas Clinic Switzerland. For 30 years, his field has been surgery of the digestive tract with specialisation in the area of the pancreas. In addition to his activities as a practising surgeon, Kaspar Z'graggen is active in science. For example, he spent two years as a fellow in the Pancreas Research Lab at Harvard Medical School and has been involved in around 100 research projects and scientific publications during his career, primarily on the subject of the pancreas.

Qualifications and specialisations


Full Professorship CHUV, University of Lausanne



1994 – 1996

Inselspital Berne (Prof. M. W. Büchler)


Specialist in Surgery FMH


Visiting Fellow, Dept. of Surgery Ninewells Hospital, University of Dundee / Scotland

1991 – 1993

Tiefenauspital Berne (Prof. F Nöthiger)


Doctorate University of Berne

1989 – 1990

Aarberg Hospital (Dr. C. Klaiber)


Medical studies FMGEMS / ECFMG


Doctor's degree

1981 – 1987

Medical studies Fribourg / Berne

Medical practice

Since 2004

Head of Swiss Pancreas Centre (since 2021 Pancreas Clinic Switzerland)

Since 2004

Affiliated physician, Beau-Site Clinic and Salem Hospital Hirslanden Berne

Sept 2003 – Aug 2004

Director and Chief Physician Clinic for Visceral Surgery and Centre for Transplantation CHUV, University of Lausanne

Oct 2002 – Aug 2003

Head of Surgical Oncology Section Surgical University Hospital Clinic for General, Visceral and Trauma Surgery Heidelberg, Germany

Oct 2001 – Sept 2002

First Senior Physician Surgical University Hospital Clinic for General, Visceral and Trauma Surgery Heidelberg, Germany

1998 – 2001

Senior Physician, Clinic for Visceral and Transplant Surgery Inselspital University of Berne

1993 – 1994

Senior Physician, Surgical Clinic Tiefenauspital Berne

In offices and boards of directors

Since 2007

Swiss Pancreas Foundation
Co-Founder and Vice-President

2014 – 2017

Siloah AG
Board of Directors

Since 2015

Ärztenetzwerk Bern Praxis AG (Doctors' Network Berne)
Board of Directors, since 2021 Chairman of the Board

2014 – 2021

Klinik Beau-Site
Establishment and management of the training centre V1 for visceral surgery


Co-founder World Pancreas Forum 
Congress President 2015, 2017, 2020 in Berne

2007 – 2014

2004 – 2017

Klinik-Beau-Site Berne
Member and President of the Medical Council


Since 2022

Pancreas Clinic Switzerland

2004 – 2021

Swiss Pancreas Centre

2001 – 2003

European Pancreas Centre of the University of Heidelberg, Germany

2003 – 2004

Full Professorship University of Lausanne

Scientific publications

A Simple Classification Of Pancreatic Duct Size and Texture Predicts Postoperative Pancreatic Fistula: A classification of the International Study Group of Pancreatic Surgery (ISGPS).

Schuh F, Mihaljevic AL, Probst P, Trudeau MT, Müller PC, Marchegiani G, Besselink MG, Uzunoglu F, Izbicki JR, Falconi M, Fernandez-Del Castillo C, Adham M, Z’graggen K, Friess H, Werner J, Weitz J, Strobel O, Hackert T, Radenkovic D, Kelemen D, Wolfgang C, Miao YI, Shrikhande SV, Lillemoe KD, Dervenis C, Bassi C, Neoptolemos JP, Diener MK, Vollmer CM Jr, Büchler MW. Ann Surg. 2021 Mar 12.

Neoadjuvant Chemotherapy in Pancreatic Cancer: An Appraisal of the Current High-Level Evidence.

Müller PC, Frey MC, Ruzza CM, Nickel F, Jost C, Gwerder C, Hackert T, Z’graggen K, Kessler U.

Pharmacology. 2021;106(3-4):143-153. 

Transpapillary endopancreatic surgery: decompression of duct system and comparison of greenlight laser with monopolar electrosurgical device in ex vivo and in vivo animal models.

Müller PC, Steinemann DC, Chinczewski L, Hatiboglu G, Nickel F, Z’graggen K, Müller-Stich BP.

Surg Endosc. 2018 Jul;32(7):3393-3400

Case-matched study of lesser versus greater curvature approach in laparoscopic Warshaw pancreatectomy.

Müller PC, Müller SA, Steinemann DC, Pärli MS, Moltzahn F, Schmid SW, Z’graggen K.

Am J Surg. 2017 Apr;213(4):711-717.

Role of proteomics to differentiate between benign and potentially malignant pancreatic cysts.

Cuoghi A, Farina A, Z’graggen K, Dumonceau JM, Tomasi A, Hochstrasser DF, Genevay M, Lescuyer P, Frossard JL.J

Proteome Res. 2011 May 6;10(5):2664-70

Chronic pancreatitis is associated with disease-specific regulatory T-cell responses.

Schmitz-Winnenthal H, Pietsch DH, Schimmack S, Bonertz A, Udonta F, Ge Y, Galindo L, Specht S, Volk C, Z’graggen K, Koch M, Büchler MW, Weitz J, Beckhove P.

Gastroenterology. 2010 Mar;138(3):1178-88

Early results from a randomized clinical trial of colon J pouch versus transverse coloplasty pouch after low anterior resection for rectal cancer.

Ulrich AB, Seiler CM, Z’graggen K, Löffler T, Weitz J, Büchler MW.

Br J Surg. 2008 Oct;95(10):1257-63

Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases.

Kleeff J, Diener MK, Z’graggen K, Hinz U, Wagner M, Bachmann J, Zehetner J, Müller MW, Friess H, Büchler MW.

Ann Surg. 2007 Apr;245(4):573-82

Specific immune recognition of pancreatic carcinoma by patient-derived CD4 and CD8 T cells and its improvement by interferon-gamma.

Schmitz-Winnenthal FH, Escobedo LV, Beckhove P, Schirrmacher V, Bucur M, Ziouta Y, Volk C, Schmied B, Koch M, Antolovic D, Weitz J, Büchler MW, Z’graggen K.

Int J Oncol. 2006 Jun;28(6):1419-28

Expression of cytokeratin-20 in pancreatic cancer: an indicator of poor outcome after R0 resection.

Schmitz-Winnenthal FH, Volk C, Helmke B, Berger S, Hinz U, Koch M, Weitz J, Kleeff J, Friess H, Zöller M, Büchler MW, Z’graggen K.

Surgery. 2006 Jan;139(1):104-8.

High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients.

Schmitz-Winnenthal FH, Volk C, Z’graggen K, Galindo L, Nummer D, Ziouta Y, Bucur M, Weitz J, Schirrmacher V, Büchler MW, Beckhove P.

Cancer Res. 2005 Nov 1;65(21):10079-87

Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility.

Gesierich S, Paret C, Hildebrand D, Weitz J, Z’graggen K, Schmitz-Winnenthal FH, Horejsi V, Yoshie O, Herlyn D, Ashman LK, Zöller M.

Clin Cancer Res. 2005 Apr 15;11(8):2840-52.

Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy.

Büchler MW, Wagner M, Schmied BM, Uhl W, Friess H, Z’graggen K.

Arch Surg. 2003 Dec;138(12):1310-4

Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.

Z’graggen K, Warshaw AL, Werner J, Graeme-Cook F, Jimenez RE, Fernández-Del Castillo C.

Ann Surg. 2001 May;233(5):688-95

Biological implications of tumor cells in blood and bone marrow of pancreatic cancer patients.

Z’graggen K, Centeno BA, Fernandez-del Castillo C, Jimenez RE, Werner J, Warshaw AL.

Surgery. 2001 May;129(5):537-46

A new surgical concept for rectal replacement after low anterior resection: the transverse coloplasty pouch.

Z’graggen K, Maurer CA,  Kern B, Büchler MW.

Ann Surg. 2001 Dec;234(6):780-5

Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1.

Werner J, Z’graggen K, Fernández-del Castillo C, Lewandrowski KB, Compton CC, Warshaw AL.

Ann Surg. 1999 Jun;229(6):834-40

Middle segment pancreatectomy: a novel technique for conserving pancreatic tissue.

Warshaw AL, Rattner DW, Fernández-del Castillo C, Z’graggen K.

Arch Surg. 1998 Mar;133(3):327-31

Metastases to the pancreas and their surgical extirpation.

Z’graggen K, Fernández-del Castillo C, Rattner DW, Sigala H, Warshaw AL.

Arch Surg. 1998 Apr;133(4):413-7

Cytotoxic cells are activated in cellular infiltrates of alcoholic chronic pancreatitis.

Hunger RE, Mueller C, Z’graggen K, Friess H, Büchler MW.

Gastroenterology. 1997 May;112(5):1656-63.

The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease.

Z'Graggen K, Walz A, Mazzucchelli L, Strieter RM, Mueller C.

Gastroenterology. 1997 Sep;113(3):808-16.

Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.

Z’graggen K, Rivera JA, Compton CC, Pins M, Werner J, Fernández-del Castillo C, Rattner DW, Lewandrowski KB, Rustgi AK, Warshaw AL.

Ann Surg. 1997 Oct;226(4):491-8

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Enquiries and contact

Prof. Dr. med. Z'graggen and his team look forward to welcoming you to the Pancreas Clinic Switzerland. If you are unsure about our services or have any other questions, we are at your disposal: Get in touch.

Lic. phil. Nathalie Weber, our clinic manager, will be happy to help you!

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